September 26, 2025
Development of a machine learning-based depression risk identification tool for older adults with asthma | BMC Psychiatry
  • Andresen EM, Malmgren JA, Carter WB, Patrick DL. Screening for depression in well older adults: evaluation of a short form of the CES-D (Center for epidemiologic studies depression Scale). Am J Prev Med. 1994;10:77–84.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Bonham CA, Patterson KC, Strek ME. Asthma outcomes and management during pregnancy. Chest. 2018;153:515–27.

    Article 
    PubMed 

    Google Scholar 

  • Braund TA, Tillman G, Palmer DM, Gordon E, Rush AJ, Harris AWF. Antidepressant side effects and their impact on treatment outcome in people with major depressive disorder: an iSPOT-D report. Transl Psychiatry. 2021;11:417.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Choi HG, Kim JH, Park JY, Hwang YI, Jang SH, Jung KS. Association between asthma and depression: A National cohort study. J Allergy Clin Immunol Pract. 2019;7:1239–e12451231.

    Article 
    PubMed 

    Google Scholar 

  • Connolly MJ, Yohannes AM. The impact of depression in older patients with chronic obstructive pulmonary disease and asthma. Maturitas. 2016;92:9–14.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Ee C, Lake J, Firth J, Hargraves F, de Manincor M, Meade T, Marx W, Sarris J. An integrative collaborative care model for people with mental illness and physical comorbidities. Int J Ment Health Syst. 2020;14:83.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Eisner MD, Katz PP, Lactao G, Iribarren C. Impact of depressive symptoms on adult asthma outcomes. Ann Allergy Asthma Immunol. 2005;94:566–74.

    Article 
    PubMed 

    Google Scholar 

  • Gao X, Geng T, Jiang M, Huang N, Zheng Y, Belsky DW, Huang T. Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK biobank participants. Nat Commun. 2023;14:2277.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Hutter N, Knecht A, Baumeister H. Health care costs in persons with asthma and comorbid mental disorders: a systematic review. Gen Hosp Psychiatry. 2011;33:443–53.

    Article 
    PubMed 

    Google Scholar 

  • Jiang M, Qin P, Yang X. Comorbidity between depression and asthma via immune-inflammatory pathways: a meta-analysis. J Affect Disord. 2014;166:22–9.

    Article 
    PubMed 

    Google Scholar 

  • Kim RY, Pinkerton JW, Essilfie AT, Robertson AAB, Baines KJ, Brown AC, Mayall JR, Ali MK, Starkey MR, Hansbro NG, Hirota JA, Wood LG, Simpson JL, Knight DA, Wark PA, Gibson PG, O’Neill LAJ, Cooper MA, Horvat JC, Hansbro PM. Role for NLRP3 Inflammasome-mediated, IL-1beta-Dependent responses in severe, Steroid-Resistant asthma. Am J Respir Crit Care Med. 2017;196:283–97.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Kohn R, Saxena S, Levav I, Saraceno B. The treatment gap in mental health care. Bull World Health Organ. 2004;82:858–66.

    PubMed 
    PubMed Central 

    Google Scholar 

  • Kolobaric A, Andreescu C, Jašarević E, Hong CH, Roh HW, Cheong JY, Kim YK, Shin TS, Kang CS, Kwon CO, Yoon SY, Hong SW, Aizenstein HJ, Karim HT, Son SJ. Gut Microbiome predicts cognitive function and depressive symptoms in late life. Mol Psychiatry. 2024;29:3064–75.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ma M, Li G, Qi M, Jiang W, Zhou R. Inhibition of the inflammasome activity of NLRP3 attenuates HDM-Induced allergic asthma. Front Immunol. 2021;12:718779.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • McDonald VM, Hamada Y, Agusti A, Gibson PG. Treatable traits in asthma: the importance of extrapulmonary traits-GERD, crswnp, atopic dermatitis, and depression/anxiety. J Allergy Clin Immunol Pract. 2024;12:824–37.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Mehta KM, Yaffe K, Covinsky KE. Cognitive impairment, depressive symptoms, and functional decline in older people. J Am Geriatr Soc. 2002;50:1045–50.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Melen E, Zar HJ, Siroux V, Shaw D, Saglani S, Koppelman GH, Hartert T, Gern JE, Gaston B, Bush A, Zein J. Asthma inception: epidemiologic risk factors and natural history across the life course. Am J Respir Crit Care Med. 2024;210:737–54.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Miller RL, Grayson MH, Strothman K. Advances in asthma: new Understandings of asthma’s natural history, risk factors, underlying mechanisms, and clinical management. J Allergy Clin Immunol. 2021;148:1430–41.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Osadnik CR, Gleeson C, McDonald VM, Holland AE. Pulmonary rehabilitation versus usual care for adults with asthma. Cochrane Database Syst Rev. 2022;8:CD013485.

    PubMed 

    Google Scholar 

  • Papi A, Brightling C, Pedersen SE, Reddel HK, Asthma. Lancet. 2018;391:783–800.

    Article 
    PubMed 

    Google Scholar 

  • Pappa S, Shah M, Young S, Anwar T, Ming T. Health-care utilisation and associated economic burden in major depressive disorder and treatment-resistant depression in a longitudinal population-based cohort study of 110.000 patients. J Psychiatr Res. 2024;180:511–8.

    Article 
    PubMed 

    Google Scholar 

  • Peng G, Cheng B, Ding R, Dai A. Research trends and hotspots on asthma and depression: A bibliometric analysis. J Asthma Allergy. 2024;17:1271–85.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Qin X, Hsieh CR. Understanding and addressing the treatment gap in mental healthcare: economic perspectives and evidence from China. Inquiry. 2020;57:46958020950566.

    Article 
    PubMed 

    Google Scholar 

  • Reddel HK, Bacharier LB, Bateman ED, Brightling CE, Brusselle GG, Buhl R, Cruz AA, Duijts L, Drazen JM, FitzGerald JM, Fleming LJ, Inoue H, Ko FW, Krishnan JA, Levy ML, Lin J, Mortimer K, Pitrez PM, Sheikh A, Yorgancioglu AA, Boulet LP. Global initiative for asthma strategy 2021: executive summary and rationale for key changes. Am J Respir Crit Care Med. 2022;205:17–35.

    Article 
    PubMed 

    Google Scholar 

  • Richardson LP, Russo JE, Lozano P, McCauley E, Katon W. The effect of comorbid anxiety and depressive disorders on health care utilization and costs among adolescents with asthma. Gen Hosp Psychiatry. 2008;30:398–406.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Sajjadian M, Lam RW, Milev R, Rotzinger S, Frey BN, Soares CN, Parikh SV, Foster JA, Turecki G, Muller DJ, Strother SC, Farzan F, Kennedy SH, Uher R. Machine learning in the prediction of depression treatment outcomes: a systematic review and meta-analysis. Psychol Med. 2021;51:2742–51.

    Article 
    PubMed 

    Google Scholar 

  • Shatte ABR, Hutchinson DM, Teague SJ. Machine learning in mental health: a scoping review of methods and applications. Psychol Med. 2019;49:1426–48.

    Article 
    PubMed 

    Google Scholar 

  • Shen L, Xu X, Yue S, Yin S. A predictive model for depression in Chinese middle-aged and elderly people with physical disabilities. BMC Psychiatry. 2024;24:305.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Sorrells SF, Sapolsky RM. An inflammatory review of glucocorticoid actions in the CNS. Brain Behav Immun. 2007;21:259–72.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Surve TAN, Sharma DD, Khan KG, Ghanie N, Charanrak R, Sharifa M, Begum S, Auz MJ, Akbarova N, Mylavarapu M. A comprehensive review of the intersection between asthma and depression. J Asthma. 2024;61:895–904.

    Article 
    PubMed 

    Google Scholar 

  • Wu R, Zhang G, Guo M, Li Y, Qin L, Jiang T, Li P, Wang Y, Wang K, Liu Y, He Z, Cheng Z. Assessing personalized molecular portraits underlying endothelial-to-mesenchymal transition within pulmonary arterial hypertension. Mol Med. 2024;30:189.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Xia CY, Guo YX, Lian WW, Yan Y, Ma BZ, Cheng YC, Xu JK, He J, Zhang WK. The NLRP3 inflammasome in depression: potential mechanisms and therapies. Pharmacol Res. 2023;187:106625.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Ye G, Baldwin DS, Hou R. Anxiety in asthma: a systematic review and meta-analysis. Psychol Med. 2021;51:11–20.

    Article 
    PubMed 

    Google Scholar 

  • Zhai X, Tong HHY, Lam CK, Xing A, Sha Y, Luo G, Meng W, Li J, Zhou M, Huang Y, Wong LS, Wang C, Li K. Association and causal mediation between marital status and depression in seven countries. Nat Hum Behav. 2024;8:2392–405.

    Article 
    PubMed 

    Google Scholar 

  • Zhang G, Wang Z, Tong Z, Qin Z, Su C, Li D, Xu S, Li K, Zhou Z, Xu Y, Zhang S, Wu R, Li T, Zheng Y, Zhang J, Cheng K, Tang J. AI hybrid survival assessment for advanced heart failure patients with renal dysfunction. Nat Commun. 2024;15:6756.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Zhao Y, Hu Y, Smith JP, Strauss J, Yang G. Cohort profile: the China health and retirement longitudinal study (CHARLS). Int J Epidemiol. 2014;43:61–8.

    Article 
    PubMed 

    Google Scholar 

  • Zhao Y, Yang L, Sahakian BJ, Langley C, Zhang W, Kuo K, Li Z, Gan Y, Li Y, Zhao Y, Yu J, Feng J, Cheng W. The brain structure, immunometabolic and genetic mechanisms underlying the association between lifestyle and depression. Nat Mental Health. 2023;1:736–50.

    Article 

    Google Scholar 

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